I just had my first call from a friend who got the Sasser Virus. The sad thing is that she works in a company where there are i.t. people responsible for ensuring that she is safe.
An important thing to stress with clients/friends/my parents (aiming here at people who are not computer professionals) is that as soon as Microsoft announces and releases out a windows patch, the virus writers are quickly behind them to get all of the people who did not update windows (what's your guess? - mine is 90% of windows users).
I happen to use Symantec Norton AntiVirus and use their SPARC website as my first place to look for help. Here they already have removal tools, etc.