I've been using PCAnywhere for many many many years. Many, as in: I remember using it when it was a DOS application!
With my client that I have VPN access to, Remote Desktop in Windows alleviated some of the need for PCAnywhere. Though RDP is great when I need to do stuff on their computers after hours, I can't work with someone, which I often like to do with remote clients who need some guidance. Remote Desktop does have an "Ask for help" feature which the client can initiate, but generally that means sitting on the phone and walking them through how to do that, which kind of defeats the purpose of getting on their computer to do something for them or show them how.
What I didn't know until recently is that I can initiate a session from my end, but the feature is kind of buried that even though I now know it's there, I still have a hard time finding it.
The feature is "Offer Remote Assistance". In WinXP & 2003 Server, you start by going to Help & Support.
Then click on the “Use Tools to view your computer information and diagnose problems“. It's not very intuitive, since I'm not trying to do either of the tasks it describes! This is the XP screenshot. It's a little different for 2003 Server.
In the Tools screen, you will see Offer Remote Assistance. . On the server, you have to open up the node for “Help & Support Center Tools“ to see it. (on the right)
WinXP
Windows 2003 Server
From here you can type in the IP address of the person. They will have to accept your offer which gets you on their computer. Then if you want to "drive" you need to click a button for "Take Control" and they need to respond to that.
Using the Offer Assistance also assumes that the network and client's security will allow it. In my case, it's okay, since I happen to be already VPNd to the client's network. In cases where I'm just not allowed on, we revert to a LiveMeeting/WebEx solution. The problem for me with this is that I now have FOUR of these apps on my computer to accommodate various clients and of course there's the cost to whoever has the account. But, in the long run, if it's the solution that works, it's certainly worth it.
Back to the Offer Remote Assistance.... there is some firewall setup to do on the client end to get this to work. I let the admin there take care of those problems. Here is a technet link for more info. I've been really happy using it.
The only thing that PCAnywhere still has the big advantage of is it's technology for fast file transfers. Transferring large files over RDP is definitely a PIA.